Also known as the Sonoran Desert Toad, is native to the desert regions of Mexico and produces a secretion containing 5-MeO-DMT, one of the most potent naturally occurring psychedelic compounds. This substance has been used in sacred rituals and healing practices for its profound, fast-acting effects on the mind and consciousness. A typical Bufo experience lasts between 5 and 30 minutes, yet it often evokes a deep sense of timelessness and a powerful expansion of consciousness that transcends the mind and body. Research from Johns Hopkins University suggests that 5-MeO-DMT shows promise in alleviating conditions such as depression, addiction, anxiety, PTSD, and supporting neuroregeneration. When used in a ceremonial setting, it can foster lasting feelings of life satisfaction, inner peace, and emotional healing. However, it is crucial to approach this powerful medicine with full awareness, ensuring that the experience is guided by a skilled and experienced facilitator for safety and integration.